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Of interest, no reduction in the risk for cardiovascular events was observed in CVOTs of dipeptidyl peptidase-4 inhibitors (DPP-4i), which prolong the half-life of endogenous GLP-1 and GIP [5,6,7,8,9]

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9,10 Additionally, GLP-1 RAs suppress glucagon secretion from the -cells in the pancreas, leading to decreased blood glucose levels

doi:10.1021/ja01581a033